In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process

Figure 2

Influence of “therapeutic” intraperitoneal application (once daily from day 22 until day 42 after the first dose of collagen) of phage lysates, sonicate of their hosts, and broth (0.5 ml/mouse) on the course of CIA. (a) T4 phage lysate (2.5 × 10⁹ pfu/mouse) and its host E. coli B strain sonicate (number of mice in groups: = 7–12). (b) Pseudomonas 119x phage lysate (6 × 10⁵ pfu/mouse) and its host P. aeruginosa 119x strain sonicate (number of mice in groups: = 10–12). (c) Enterococcal 15/P phage lysate (3.25 × 10⁶ pfu/mouse) and its host E. faecalis 26589 strain sonicate (number of mice in groups: = 10–12). (d) Staphylococcal A3/R phage lysate (4 × 10⁸ pfu/mouse) and its host S. aureus 19930 strain sonicate (number of mice in groups: = 9–11). (e) MS-1 staphylococcal phage lysate containing an equal mixture of A5/80, P4/6409, and 676/Z phages, and sonicate of relevant mixture of their host strains (S. aureus 80, S. aureus 6409, and S. aureus 11788) (number of mice in groups: ). (f) Broth used in the process of phage propagation (number of mice in groups: = 10-11). in comparison to the control group (Mann–Whitney U test). For clarity reasons only upper or lower error bars representing SE are shown.

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