In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process

Figure 4

Influence of “therapeutic” intraperitoneal application of purified T4 phage preparation on the course of CIA. Dose of T4 phage in PBS: 5 × 10⁸ pfu/mouse once daily from day 22 until day 42 after the first dose of collagen. Control mice received 0.5 ml of PBS i.p. Number of mice in groups: = 8–10. Methotrexate dose: 10 mg/kg three times a week (). in comparison to the control group (Mann–Whitney U test). For clarity reasons only upper or lower error bars representing SE are shown.