In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process
Table 3
Influence of MS-1 staphylococcal phage mixture on lymphocyte populations of thymus, spleen, and mesenteric lymph nodes 21 days after ending of its therapeutic application in CIA model in mice.
Cell population
Phenotype
Control
Bacterial sonicate
MS-1 (lysate)
Mean
±SE [%]
Mean
±SE [%]
Mean
±SE [%]
Thymocytes
CD8+
10
2.1
±0.1
10
1.6
±0.2
10
2.3
±0.3
CD4+
10
12.2
±0.9
10
12.4
±0.7
10
13.0
±1.1
CD4+CD8+
10
79.6
±1.5
10
75.0
±7.7
10
77.9
±1.5
CD4−CD8−
10
6.1
±0.7
10
3.0
±0.9
10
6.8
±1.
Splenocytes
CD3+
9
17.5
±0.5
10
26.7
±4.6
10
22.1
±1.1
CD19+
9
75.2
±1.5
10
67.2
±5.3
10
71.4
±0.9
CD8+
10
2.4
±0.2
10
3.5
±0.
10
3.3
±0.3
CD4+
10
7.7
±0.4
10
11.3
±0.
10
10.7
±0.
CD4+CD8+
10
2.6
±0.6
10
1.6
±0.4
10
1.6
±0.3
CD4−CD8−
10
87.3
±0.9
10
83.6
±0.
10
84.7
±0.9
Mesenteric lymph node cells
CD3+
9
32.7
±1.1
10
35.5
±1.2
7
35.6
±1.7
CD19+
9
58.4
±2.5
10
57.7
±2.0
7
58.1
±1.2
CD8+
9
4.8
±0.5
9
4.8
±0.2
7
5.1
±0.3
CD4+
9
18.7
±0.7
9
24.6
±1.
7
23.3
±2.1
CD4+CD8+
9
6.7
±2.9
9
3.2
±0.4
7
2.6
±0.8
CD4−CD8−
9
69.8
±3.1
9
67.4
±1.1
7
69.0
±2.0
when compared to control group (one-way ANOVA, post hoc Scheffe’s test); when compared to bacterial sonicate treated group (one-way ANOVA, post hoc Scheffe’s test).
