Research Article
Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method
Table 1
The interday and intraday precision, accuracy, and recovery for five probes.
| Compound | Nominal concentration (ng/mL) | Interday precision measured (ng/mL) | RSD (%) | Accuracy RE (%) | Intraday precision measured (ng/mL) | RSD (%) | Accuracy RE (%) | Recovery mean ± SD (%) | RSD (%) |
| Phenacetin | 10 | | 9.4 | −1.0 | | 5.4 | −4.6 | | 3.1 | 250 | | 6.8 | −5.2 | | 7.1 | −3.9 | | 5.6 | 5000 | | 7.0 | 1.1 | | 1.3 | 3.0 | | 4.5 |
| Tolbutamide | 20 | | 7.7 | 5.1 | | 4.2 | 2.5 | | 2.3 | 500 | | 5.3 | 0.9 | | 3.2 | −1.4 | | 6.0 | 10000 | | 6.5 | −2.1 | | 4.0 | −3.5 | | 6.5 |
| Omeprazole | 15 | | 3.7 | 1.9 | | 3.8 | 3.6 | | 4.3 | 150 | | 7.3 | −1.7 | | 9.2 | −1.6 | | 6.4 | 1500 | | 4.6 | 4.7 | | 3.1 | 4.7 | | 2.7 |
| Metoprolol | 10 | | 4.4 | −2.8 | | 4.7 | −2.8 | | 2.9 | 100 | | 7.4 | 0.2 | | 6.1 | 0.6 | | 8.2 | 1000 | | 8.9 | 6.4 | | 9.1 | 5.9 | | 7.3 |
| Midazolam | 10 | | 2.7 | −5.0 | | 5.8 | −1.4 | | 6.3 | 100 | | 8.5 | 2.4 | | 7.9 | 9.0 | | 5.6 | 1000 | | 11.4 | 2.2 | | 4.6 | 1.8 | | 7.7 |
|
|