Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Table 1

The interday and intraday precision, accuracy, and recovery for five probes.

Compound	Nominal; concentration; (ng/mL)	Interday; precision; measured (ng/mL)	RSD (%)	Accuracy; RE (%)	Intraday; precision; measured (ng/mL)	RSD (%)	Accuracy; RE (%)	Recovery; mean ± SD; (%)	RSD (%)
Phenacetin	10		9.4	−1.0		5.4	−4.6		3.1
	250		6.8	−5.2		7.1	−3.9		5.6
	5000		7.0	1.1		1.3	3.0		4.5
Tolbutamide	20		7.7	5.1		4.2	2.5		2.3
	500		5.3	0.9		3.2	−1.4		6.0
	10000		6.5	−2.1		4.0	−3.5		6.5
Omeprazole	15		3.7	1.9		3.8	3.6		4.3
	150		7.3	−1.7		9.2	−1.6		6.4
	1500		4.6	4.7		3.1	4.7		2.7
Metoprolol	10		4.4	−2.8		4.7	−2.8		2.9
	100		7.4	0.2		6.1	0.6		8.2
	1000		8.9	6.4		9.1	5.9		7.3
Midazolam	10		2.7	−5.0		5.8	−1.4		6.3
	100		8.5	2.4		7.9	9.0		5.6
	1000		11.4	2.2		4.6	1.8		7.7