Influences of Anlotinib on Cytochrome P450 Enzymes in Rats Using a Cocktail Method

Table 2

Main pharmacokinetic parameters of five in rats (, mean ± SD).

Probe drugs	Parameters	, h	CL, L/h/kg	, ng/ml	, h	, ng/ml⋅h	, ng/ml⋅h
Phenacetin	Control
	Anlotinib
Tolbutamide	Control
	Anlotinib
Omeprazole	Control
	Anlotinib
Metoprolol	Control
	Anlotinib
Midazolam	Control
	Anlotinib

different from control, . different from control, .