Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells

<div><i>Cytopathic effects of recombinant vaccinia viruses on tumor cell growth</i>. (a) MDA-MB-231 and MX-7 cells were infected with various concentration of VVs (0.06–2 PFU/cell) for 72 h. The relative survival of infected tumor cells was detected by MTT test. The data represent the mean ± SD. (b) Visualization of lytic (apoptotic) morphology of infected MDA-MB-231 cells. Cells were infected with VV-GMCSF-dGF, VV-GMCSF-Lact, and VV-GMCSF-Apo. At 6, 24, and 48 h after infection, cells were analyzed by inverted microscope (phase-contrast) and photographed. Representative photomicrographs of three independent experiments.</div>

BioMed Research International

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Figure 2: Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells 

Figure 2 | Recombinant Vaccinia Viruses Coding Transgenes of Apoptosis-Inducing Proteins Enhance Apoptosis But Not Immunogenicity of Infected Tumor Cells 