A Study of IL-1β, MMP-3, TGF-β1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population

Table 3

Comparisons of genotype and allele distributions of IL-1β, MMP-3, TGF-β1, and GDF5 polymorphisms between patients with PFS and controls.

SNP	Cases	Controls	OR (95% CI)	value
	(%)	(%)
IL-1; rs1143627
Genotype
TT	14 (33.3)	15 (30.0)	1.00
TC	26 (61.9)	22 (44.0)	1.27 (0.50–3.19)	0.616
CC	2 (4.8)	13 (26.0)	0.17 (0.03–0.87)	0.022
TC + CC	28 (66.7)	35 (35.0)	0.86 (0.36–2.07)	0.732
Allele
T	54 (64.3)	52 (52.0)	1.00
C	30 (35.7)	48 (48.0)	0.60 (0.33–1.09)	0.093
MMP-3; rs650108
Genotype
AA	18 (42.9)	20 (40.0)	1.00
AG	16 (48.1)	21 (42.0)	0.85 (0.34–2.10)	0.720
GG	8 (19.0)	9 (18.0)	0.99 (0.34–3.11)	0.983
AG + GG	24 (67.1)	30 (60.0)	0.89 (0.39–2.04)	0.782
Allele
A	52 (61.9)	61 (61.0)	1.00
G	32 (38.1)	39 (39.0)	0.96 (0.53–1.75)	0.900
TGF-β1; rs1800469
Genotype
CC	9 (21.4)	13 (26.0)	1.00
CT	23 (54.8)	24 (48.0)	1.38 (0.50–0.39)	0.533
TT	10 (23.8)	13 (26.0)	1.11 (0.34–3.63)	0.862
CT + TT	33 (78.6)	37 (74.0)	1.29 (0.49–3.40)	0.609
Allele
C	41 (48.9)	50 (50.0)	1.00
T	43 (51.1)	50 (50.0)	1.05 (0.59–1.87)	0.872
GDF5; rs143383
Genotype
TT	22 (52.4)	24 (48.0)	1.00
TC	18 (42.9)	22 (44.0)	0.89 (0.38–2.09)	0.793
CC	2 (4.8)	4 (8.0)	1.54 (0.42–5.64)	0.513
TC + CC	20 (47.7)	26 (52.0)	0.84 (0.37–1.91)	0.675
Allele
T	62 (73.8)	70 (70.0)	1.00
C	22 (26.2)	30 (30.0)	1.07 (0.58–1.98)	0.828

Reference genotype/allele; CI: confidence interval; OR: odds ratio; PFS: primary frozen shoulder; SNP: single nucleotide polymorphism.