Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice

Figure 2

Infertility accompanied by high plasma T levels in male α−/− mice. (a) Percent of litter-producing matings by males (α+/+, ; α−/−, ). Plasma LH (b) and FSH (c) levels ( per group). (d) Plasma T levels (α+/+, ; α−/−, ). (e) Testicular weight (α+/+, ; α−/−, ). (f) Total sperm count per epididymis (α+/+, ; α−/−,  ). (g) Percentage of motile sperm (α+/+, ; α−/−, ). (h) Representative transverse sections of α+/+ and α−/− mice showing normal seminiferous tubules with all types of spermatogenic elements (Sz, spermatozoa,; Sc, spermatocytes; Sp, spermatids). Scale bar corresponds to 50 μm. Values are mean ± SEM (Student’s -test as compared to control). .

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