Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice

Figure 4

The mRNA levels of ERα are lower in the testis of PND30 and adult α−/− males compared to controls. Relative mRNA levels of testicular LepR (a), the IR (b), the AR (c), and ERα (d) normalized to β-actin in PND30 males. Relative mRNA levels of testicular LepR (e), the IR (f), the AR (g), and ERα (h) normalized to β-actin in adult males. Values are mean ± SEM (Student’s -test as compared to control). , per genotype from PND30 mice; = 5-6 per genotype from adult animals.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)