Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice

Table 2

Body weight, plasma leptin and estradiol levels, and white adipose tissue mRNA levels of leptin and TNF-α in PND30 and adult α+/+ and α−/− males.

	PND30		Adult (3-4 mo.)
	α+/+	α−/−	α+/+	α−/−
Body weight (g)	()	()	()	()
Fasted plasma leptin (ng/mL)	()	()	()	()
Plasma E2 (pg/mL)	NA	NA	()	()
WAT leptin (a.u) (fasted)	()	()	NA	NA
WAT TNF-α (a.u); (nonfasted)	()	()	()	()

Data are means ± SEM. aP2-Cre/p110 mice are referred to as α−/−; control p110 mice are referred to as α+/+. and . E₂, estradiol, WAT, white adipose tissue, NA, not available.