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BioMed Research International
Volume 2017, Article ID 3762179, 3 pages
Research Article

Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone

Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

Correspondence should be addressed to Takatsugu Yamamoto;

Received 27 August 2017; Accepted 26 September 2017; Published 7 December 2017

Academic Editor: Toshimi Chiba

Copyright © 2017 Takatsugu Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aim. Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods. We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. Results. The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (). Conclusions. Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.