Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Number of patients</td><td class="align_center">126</td></tr><tr><td class="align_left">Age (year ± SD)</td><td class="align_center">65.4 ± 15.7</td></tr><tr><td class="align_left">Sex (male/female)</td><td class="align_center">61/65</td></tr><tr><td class="align_left">Mental disorder</td><td class="align_center">13 (10.3%)</td></tr><tr><td class="align_left">Concomitant agents</td><td class="align_center"> </td></tr><tr><td class="align_left"> Laxatives</td><td class="align_center">69 (54.8%)</td></tr><tr><td class="align_left"> Prokinetics/herbal medicines</td><td class="align_center">56 (44.4%)</td></tr><tr><td class="align_left"> Probiotics</td><td class="align_center">10 (7.9%)</td></tr><tr><td class="align_left"> PPI/H2RA</td><td class="align_center">33 (26.2%)</td></tr><tr><td class="align_left">Effectiveness</td><td class="align_center">95 (75.4%)</td></tr><tr><td class="align_left">Diarrhea</td><td class="align_center">30 (23.8%)</td></tr><tr><td class="align_left">Nausea/vomiting</td><td class="align_center">16 (12.7%)</td></tr><tr><td class="align_left">Discontinuation</td><td class="align_center">53 (42%)</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Other adverse effects included edema (2 patients), headache (1 patient), and palpitation (1 patient). SD: standard deviation, PPI: proton pump inhibitor, and H2RA: histamine 2 receptor antagonist.<br/></td></tr></table>

Background characteristics and clinical response to lubiprostone.

BioMed Research International

tab1

Table 1

Table 1: Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone 