Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 3764370, 13 pages
https://doi.org/10.1155/2017/3764370
Research Article

Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Mice

1Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
2Department of Internal Medicine (VIP), The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830000, China

Correspondence should be addressed to Ling Tao; moc.liamg@6002oatgnil, Ming Yuan; nc.ude.ummf@gnimnauy, and Fu Yi; moc.liamtoh@65uf21iy

Received 2 September 2016; Revised 5 December 2016; Accepted 13 December 2016; Published 21 March 2017

Academic Editor: Fabrizio Montecucco

Copyright © 2017 Bin Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Guariguata, D. R. Whiting, I. Hambleton, J. Beagley, U. Linnenkamp, and J. E. Shaw, “Global estimates of diabetes prevalence for 2013 and projections for 2035,” Diabetes Research and Clinical Practice, vol. 103, no. 2, pp. 137–149, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Bugger and C. Bode, “The vulnerable myocardium. Diabetic cardiomyopathy,” Hamostaseologie, vol. 35, no. 1, pp. 17–24, 2015. View at Google Scholar · View at Scopus
  3. K. Trachanas, S. Sideris, C. Aggeli et al., “Diabetic cardiomyopathy: from pathophysiology to treatment,” Hellenic Journal of Cardiology, vol. 55, no. 5, pp. 411–421, 2014. View at Google Scholar · View at Scopus
  4. I. Falcão-Pires and A. F. Leite-Moreira, “Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment,” Heart Failure Reviews, vol. 17, no. 3, pp. 325–344, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. Q. Tong, X. Hou, J. Fang et al., “Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study,” Journal of Pharmaceutical and Biomedical Analysis, vol. 114, pp. 455–461, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Zhu, P. Luo, Y. Fu et al., “Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin,” Oncotarget, vol. 6, no. 5, pp. 3254–3267, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Meng, S. Yang, Y. Chen, W. Yao, H. Zhu, and W. Zhang, “Attenuating effects of dihydromyricetin on angiotensin II-induced rat cardiomyocyte hypertrophy related to antioxidative activity in a NO-dependent manner,” Pharmaceutical Biology, vol. 53, no. 6, pp. 904–912, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. Q. Zhou, K. Chen, P. Liu et al., “Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway,” Molecular and Cellular Endocrinology, vol. 412, pp. 349–357, 2015. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Shi, T. Zhang, Y. Zhou et al., “Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway,” Endocrine, vol. 50, no. 2, pp. 378–389, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Chen, X. Zhao, J. Wan et al., “Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: a randomized controlled trial,” Pharmacological Research, vol. 99, pp. 74–81, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Hou, Q. Tong, W. Wang, W. Xiong, C. Shi, and J. Fang, “Dihydromyricetin protects endothelial cells from hydrogen peroxide-induced oxidative stress damage by regulating mitochondrial pathways,” Life Sciences, vol. 130, pp. 38–46, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Shi, T. Zhang, X. Liang et al., “Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway,” Molecular and Cellular Endocrinology, vol. 409, pp. 92–102, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Zhang, Z. Zhao, M. Shen et al., “Polydatin protects cardiomyocytes against myocardial infarction injury by activating Sirt3,” Biochimica et Biophysica Acta (BBA)—Molecular Basis of Disease, 2016. View at Publisher · View at Google Scholar
  14. L. E. Wold and J. Ren, “Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism,” Biochemical and Biophysical Research Communications, vol. 318, no. 4, pp. 1066–1071, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Koncsos, Z. V. Varga, T. Baranyai et al., “Diastolic dysfunction in prediabetic male rats: role of mitochondrial oxidative stress,” American Journal of Physiology - Heart and Circulatory Physiology, vol. 311, no. 4, pp. H927–H943, 2016. View at Publisher · View at Google Scholar
  16. M. Khullar, A. A.-R. S. Al-Shudiefat, A. Ludke, G. Binepal, and P. K. Singal, “Oxidative stress: a key contributor to diabetic cardiomyopathy,” Canadian Journal of Physiology and Pharmacology, vol. 88, no. 3, pp. 233–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Boudina and E. D. Abel, “Diabetic cardiomyopathy revisited,” Circulation, vol. 115, no. 25, pp. 3213–3223, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Ye, N. S. Metreveli, R. V. Donthi et al., “Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes,” Diabetes, vol. 53, no. 5, pp. 1336–1343, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Mano, T. Anzai, H. Kaneko et al., “Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy,” Circulation Journal, vol. 75, no. 7, pp. 1717–1727, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. An and B. Rodrigues, “Role of changes in cardiac metabolism in development of diabetic cardiomyopathy,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 291, no. 4, pp. H1489–H1506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. T. H. Kuo, K. H. Moore, F. Giacomelli, and J. Wiener, “Defective oxidative metabolism of heart mitochondria from genetically diabetic mice,” Diabetes, vol. 32, no. 9, pp. 781–787, 1983. View at Publisher · View at Google Scholar · View at Scopus
  22. O. Lorenzo, B. Picatoste, S. Ares-Carrasco, E. Ramírez, J. Egido, and J. Tuñón, “Potential role of nuclear factor κB in diabetic cardiomyopathy,” Mediators of Inflammation, vol. 2011, Article ID 652097, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. J.-Q. Song, X. Teng, Y. Cai, C.-S. Tang, and Y.-F. Qi, “Activation of Akt/GSK-3β signaling pathway is involved in intermedin1–53 protection against myocardial apoptosis induced by ischemia/reperfusion,” Apoptosis, vol. 14, no. 11, pp. 1299–1307, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Dong, V. V. Undyala, R. A. Gottlieb, R. M. Mentzer Jr., and K. Przyklenk, “Autophagy: definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 15, no. 3, pp. 220–230, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. V. Varga, Z. Giricz, L. Liaudet, G. Haskó, P. Ferdinandy, and P. Pacher, “Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy,” Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1852, no. 2, pp. 232–242, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. C. He, H. Zhu, H. Li, M.-H. Zou, and Z. Xie, “Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes,” Diabetes, vol. 62, no. 4, pp. 1270–1281, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Xu, S. Kobayashi, K. Chen et al., “Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes,” The Journal of Biological Chemistry, vol. 288, no. 25, pp. 18077–18092, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. M.-H. Zou and Z. Xie, “Regulation of interplay between autophagy and apoptosis in the diabetic heart: new role of AMPK,” Autophagy, vol. 9, no. 4, pp. 624–625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Xia, S. Guo, T. Fang et al., “Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways,” Food and Chemical Toxicology, vol. 66, pp. 7–13, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. Z. Xie, C. He, and M.-H. Zou, “AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy,” Autophagy, vol. 7, no. 10, pp. 1254–1255, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. Z. Xie, K. Lau, B. Eby et al., “Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice,” Diabetes, vol. 60, no. 6, pp. 1770–1778, 2011. View at Publisher · View at Google Scholar · View at Scopus