BioMed Research International / 2017 / Article / Tab 2

Research Article

Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona

Table 2

Essential proteins of Salmonella enterica subsp. enterica serovar Poona involved in unique metabolic pathways.

Associated pathwayGene(s) nameKEGG orthology (KO)

D-Alanine metabolismAlrK01775

Vancomycin resistancealr, murGK01775, K02563

Lipopolysaccharide biosynthesislpxA, lpxC, lpxD, lpxH, lpxB, lpxK, kdtA, lpxL, kdsB, kdsA, lpxM, waaQ, waaC, waaF, waaG, waaJ,K00677, K02535, K02536, K03269, K00748, K00912, K02527, K02517, K00979, K01627, K02560, K02849, K02841, K02843, K02844, K03279,

Cationic antimicrobial peptide (CAMP) resistancelpxA, tolC, phoQ, arnT, pmrK, acrB, mexB, adeJ, smeE, mtrD, cmeBK00677, K12340, K07637, K07264, K18138

Peptidoglycan biosynthesismurA, murC, murD, murF, mraY, murG, murJK00790, K01924, K01925, K01929, K01000, K02563, K03980, K05515

Cell cyclemurG, dnaA, dnaB, ftsZ, ftsQ, ftsAK02563, K02313, K02314, K03531, K03589, K03590

Bacterial secretion systemtolC, yscJ, sctJ, hrcJ, yscT, sctT, hrcT, secD, secY, secA, tatCK12340, K03222, K03228, K03072, K03076, K03070, K03118

Two-component systemtolC, phoQ, envZ, ompR, ompF, rcsB, dnaA,glnL, ntrB,cheB, pagOK12340, K07637, K07638, K07659, K09476, K07687, K02313, K07708, K03412, K07790

Protein exportsecD, secY, secA, tatCK03072, K03076, K03070, K03118

DNA replicationdnaBK02314

Bacterial chemotaxischeBK03412

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