Application of the Subtractive Genomics and Molecular Docking Analysis for the Identification of Novel Putative Drug Targets against Salmonella enterica subsp. enterica serovar Poona

Table 3

Druggable targets, available drugs, and broad-spectrum property analysis of the shortlisted essential proteins from Salmonella enterica subsp. enterica serovar Poona.

Target number	KEEG orthology (KO)	Protein name	Broad-spectrum property	Available drug in DrugBank	DrugBank IDs
()	K01775	Alanine racemase	25	Cycloserine	DB00260
()	K00790	UDP-N-Acetyl glucosamine 1-carboxyvinyltransferase	19	Fosfomycin	DB00828
()	K05515	Penicillin-binding protein 2	8	Ceftazidime; Ertapenem	DB00438; DB00303
()	K12340	Outer membrane channel protein tolC	28	Colistin	DB00803
()	K09476	Outer membrane pore protein F	26	Polymyxin B Sulfate	DB00781
()	K03531	Cell division protein FtsZ	29	Guanosine 5′-diphosphate	DB04315
()	K01627	2-Dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase)	8	2-Phosphoglyceric acid	DB01709
()	K02563	UDP-N-Acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	29	Uridine diphosphate-N-acetylgalactosamine	DB02196
()	K07637	Two-component system, OmpR family, sensor histidine kinase PhoQ	197	Radicicol	DB03758
()	K07638	Two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ	32	Phosphoaminophosphonic acid-adenylate ester	DB04395
()	K18138	Multidrug efflux pump arcB	279	Rhodamine 6g	DB03825