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BioMed Research International
Volume 2017, Article ID 3805073, 7 pages
Research Article

Monitoring Leiomyoma Response to Uterine Artery Embolization Using Diffusion and Perfusion Indices from Diffusion-Weighted Imaging

1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
3School of Medical Imaging, Tianjin Medical University, Tianjin 300070, China
4School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
5GE Healthcare China, Shanghai 201203, China

Correspondence should be addressed to Yan Zhou; moc.liamtoh@5741eralc and Shiteng Suo; moc.liamg@ousths

Received 9 December 2016; Revised 7 July 2017; Accepted 25 July 2017; Published 27 August 2017

Academic Editor: Jiang Du

Copyright © 2017 Mengqiu Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction ) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up. Methods. Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI before and 6 months after UAE were included. ADC and perfusion fraction were calculated from DWI. The Wilcoxon signed-rank test and Spearman rank correlation test were used for statistics. Results. Seventeen fibroids were studied. The median ADCs showed a significant increase from 1.20 × 10−3 mm2/s (range, 0.86–1.66 × 10−3 mm2/s) at baseline to 1.56 × 10−3 mm2/s (range, 1.00–1.86 × 10−3 mm2/s) at 6-month follow-up (). Conversely, the median perfusion fraction was significantly decreased after UAE (), with a median pre-UAE value of 14.2% (range, 6.7%–17.6%) and a median post-UAE value of 9.2% (range, 3.2%–14.6%). Significant correlations were found between fibroid volume reduction rate and percentage changes in ADC and perfusion fraction at 6-month follow-up relative to baseline, with values of −0.50 () and 0.55 (), respectively. Conclusion. ADC and perfusion fraction obtained from DWI at 3.0 T may help to evaluate treatment response to UAE.