Former Very Preterm Infants Show Alterations in Thyroid Function at a Preschool Age

Table 2

Logistic regression analysis of thyroid hormone levels in children born very preterm in comparison to same-aged controls born at term.

Outcome variable and analysis model	coefficient	value	OR (95% CI)
Unadjusted	0.415	0.062	1.51 (0.98; 2.34)
Model A	0.479	0.044	1.62 (1.01; 2.58)
Model B	0.577	0.021	1.78 (1.09; 2.90)
Model C	0.678	0.015	1.97 (1.14; 3.39)
Unadjusted	−0.593	0.014	0.55 (0.35; 0.89)
Model A	−0.503	0.047	0.61 (0.37; 0.99)
Model B	−0.560	0.033	0.57 (0.34; 0.95)
Model C	−0.570	0.054	0.57 (0.32; 1.01)
Unadjusted	0.680	0.004	1.97 (1.24; 3.14)
Model A	0.679	0.011	1.97 (1.17; 3.32)
Model B	0.641	0.015	1.90 (1.13; 3.19)
Model C	0.663	0.019	1.94 (1.12; 3.40)

BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CI, confidence interval; fT3, free triiodothyronine; fT4, free thyroxine; OR, odds ratio(s); TSH, thyroid stimulating hormone. Model A was adjusted for age at examination and sex. Model B was adjusted for all parameters of model A plus birth weight -score and current BMI -score. Model C was adjusted for all parameters of model B plus maternal educational status and smoking during pregnancy. OR were calculated for former preterm infants in relation to same-aged children born at term. OR are reported as OR per SD increase. Input data were logarithmically transformed for analyses.