Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone

Table 2

Characteristics of the 125 patients grouped by NLR and CEA.

Variables	Sum (%)	NLR			CEA (ng/mL)
		≥2.43	<2.43	value	≥5	<5	value
Age (year)
<65	70 (56)	32	38	0.587	23	47	0.265
≥65	55 (44)	22	33		24	31
Gender
Female	52 (0.42)	24	28	0.588	22	30	0.454
Male	73 (0.58)	30	43		25	48
Smoking
Yes	116 (0.92)	50	66	1.000	45	71	0.481
No	9 (0.08)	4	5		2	7
Family history
No	118 (0.944)	51	67	1.000	45	73	0.710
Yes	7 (0.056)	3	4		2	5
Cancer site
Rectum	88 (0.7)	31	57	0.006	32	56	0.689
Colon	37 (0.3)	23	14		15	22
Histologic class
AC	120 (0.96)	50	70	0.165	45	75	1.000
NAC	5 (0.04)	4	1		2	3
Differentiation
Well/moderate	4 (0.03)	4	0	0.033	1	3	0.663
Poor	121 (0.97)	50	71		46	75
Tumor stage
II	56 (0.452)	20	36	0.149	18	38	0.272
III	68 (0.548)	34	35		29	40
Tumor size (cm)
<5	116 (0.92)	45	64	0.289	38	71	0.165
≥5	9 (0.08)	9	7		9	7
Fib (g/mL)
<3.30	47 (0.38)	19	29	0.580	11	37	0.008
≥3.30	76 (0.62)	35	42		36	41
RBC (×10^12/mL)
<4.43	77 (0.62)	38	39	0.095	28	49	0.850
≥4.43	48 (0.38)	16	32		19	29
PLR
<113.5	48 (0.38)	4	44	<0.001	18	30	1.000
≥113.5	77 (0.62)	50	27		29	48
NLR
<2.43	71 (0.57)	—	—	—	24	47	0.354
≥2.43	54 (0.43)	—	—		23	31
CEA (ng/mL)
<5	78 (0.72)	31	47	0.206	—	—	—
≥5	47 (0.38)	23	24		—	—
CA199 (U/mL)
<7.42	50 (0.40)	18	32	0.202	13	37	0.038
≥7.42	75 (0.60)	36	39		34	41

Fib = fibrinogen; RBC = red blood cell; PLR = platelet-to-lymphocyte ratio; NLR = neutrophil-to-lymphocyte ratio; CEA = carcinoembryonic antigen; CA199 = carbohydrate antigen 199; COCN = combination of CEA and NLR; AC = adenocarcinoma; NAC = nonadenocarcinoma.