Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone

Table 4

Multivariate Cox regression survival analysis for all patients undergoing surgery ().

Variables	OS			DFS
	HR	95% CI	value	HR	95% CI	value
NLR (≥2.43 versus <2.43)	2.571	0.968–6.832	0.058	2.229	1.012–4.911	0.047
CEA (≥5 ng/mL versus <5 ng/mL)	3.713	1.396–9.873	0.009	3.652	1.630–8.179	0.002
COCN ()	3.106	1.576–6.123	0.001	3.139	1.800–5.472	<0.001
Tumor stage	3.384	0.972–11.778	0.055	2.449	0.978–6.131	0.056

NLR = neutrophil-to-lymphocyte ratio; CEA = carcinoembryonic antigen; COCN = combination of CEA and NLR; HR = hazard ratio; OS = overall survival; DFS = disease-free survival.