Imaging Diagnosis of Right Ventricle Involvement in Chagas Cardiomyopathy

Figure 1

Histological analysis (HE) depicting normal cardiac fibers with regular interstitial space in the right (a) and left (b) ventricles. In a T. cruzi-infected mice, with 30 days post-Chagas infection (acute phase), there is an intense and diffuse myocarditis characterized by lymphomononuclear interstitial infiltrate (white arrow), multiple ruptured or unruptured pseudocysts (black arrow), and enlargement of the interstitial space ((c) and (d)). After 100 days of infection (chronic phase), the number of the lymphomononuclear inflammatory cells became significantly reduced and no parasites are detected ((e) and (f)). In this study, the numbers of interstitial mononuclear cells were quantified in both right and left ventricles. The number of cells was markedly increased at 30 days of infection as compared to 100 days of infection, mostly in the right ventricle ((g) and (h)). Bars = 100 μm, /day/group. HE = Hematoxylin-Eosin stain. Adapted from [11]. Adapted with permission from Elsevier, license number 4120251034702.

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