Chlamydial Type III Secretion System Needle Protein Induces Protective Immunity against Chlamydia muridarum Intravaginal Infection

Figure 8

Prime-boost immunization with AdTC_0037/rTC_0037-MPLA affects oviduct pathology in Chlamydia muridarum BALB/c mice. Mice were immunized with AdTC_0037/rTC_0037-MPLA, challenged intravaginally with C. muridarum, and sacrificed 30 days after infection. Oviducts were analyzed for the presence of a hydrosalpinx. (a) Hydrosalpinges in ovaries collected from unvaccinated mice, compared to the complete absence of oviduct pathology in vaccinated mice (b). (c) Percent of mice with reduced pathology in AdTC_0037-immunized groups.

(a)

(b)

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