Safety and Efficacy of First-Line Treatments for Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Indirect Comparison

Figure 4

Top 10 most frequent adverse events (EAs) among all clinical trials. Fatigue ranks first, back pain ranks second, and vomiting ranks last. Risk ratio (RR) is used to express the difference in AEs, with RR < 1 favoring the treatment.