Safety and Efficacy of First-Line Treatments for Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Indirect Comparison

Figure 5

Pooled analysis of the chemotherapy subgroup (mitoxantrone, docetaxel, and cabazitaxel). Hazard ratio (HR) is used to indicate differences in overall survival (OS) and progression-free survival (PFS), while risk ratio (RR) is used for PSA response and adverse events (AEs). An HR or RR < 1 favors that treatment group. First rank indicates superior outcome (excluding AEs). PSA: prostate-specific antigen.