Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 3971259, 10 pages
https://doi.org/10.1155/2017/3971259
Review Article

A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Tumor Etiology and Screening Department, Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, Liaoning 110001, China

Correspondence should be addressed to Li-ping Sun; nc.ude.umc@nuspl and Yuan Yuan; nc.ude.umc@nauynauy

Received 29 November 2016; Accepted 20 March 2017; Published 3 April 2017

Academic Editor: Jinsong Ren

Copyright © 2017 Hao Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. D. Robertson, “DNA methylation, methyltransferases, and cancer,” Oncogene, vol. 20, no. 24, pp. 3139–3155, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Razin and A. D. Riggs, “DNA methylation and gene function,” Science, vol. 210, no. 4470, pp. 604–610, 1980. View at Publisher · View at Google Scholar · View at Scopus
  3. M. W. Łuczak and P. P. Jagodziński, “The role of DNA methylation in cancer development,” Folia Histochemica et Cytobiologica, vol. 44, no. 3, pp. 143–154, 2006. View at Google Scholar · View at Scopus
  4. M. T. McCabe, J. C. Brandes, and P. M. Vertino, “Cancer DNA methylation: molecular mechanisms and clinical implications,” Clinical Cancer Research, vol. 15, no. 12, pp. 3927–3937, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Turek-Plewa and P. P. Jagodziński, “The role of mammalian DNA methyltransferases in the regulation of gene expression,” Cellular and Molecular Biology Letters, vol. 10, no. 4, pp. 631–647, 2005. View at Google Scholar · View at Scopus
  6. G. Xiang, F. Zhenkun, C. Shuang et al., “Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among chinese han women in the heilongjiang province,” Clinical Breast Cancer, vol. 10, no. 5, pp. 373–377, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Y. Sun, Association study of single nucleotide polymorphisms in estrogen synthesis, metabolism-related genes, and DNMTs with the susceptibility of breast cancer among Han Chinese women [M.S. thesis], Nanfang Medical University, Guangzhou, China, 2012.
  8. F. Khatami, B. Noorinayer, S. Ghiasi, R. Mohebi, M. Hashemi, and M. R. Zali, “Lack of effects of single nucleotide polymorphisms of the DNA methyltransferase 1 gene on gastric cancer in Iranian patients: a case control study,” Asian Pacific Journal of Cancer Prevention, vol. 10, no. 6, pp. 1177–1182, 2009. View at Google Scholar · View at Scopus
  9. J. Jiang, Z. Jia, D. Cao et al., “Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of helicobacter pylori infection and increased risks of gastric atrophy,” PLoS ONE, vol. 7, no. 9, Article ID e46058, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. X.-X. Yang, X.-Q. He, F.-X. Li, Y.-S. Wu, Y. Gao, and M. Li, “Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population,” International Journal of Molecular Sciences, vol. 13, no. 7, pp. 8364–8378, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. B.-S. He, Y.-Q. Pan, and C.-B. Zhu, “Polymorphisms of DNA methyltransferases and the risk of prostate cancer,” Zhonghua Nan Ke Xue, vol. 20, no. 12, pp. 1077–1081, 2014. View at Google Scholar · View at Scopus
  12. L. Wang, “Correlation of DNA methyctransferase 1 gene polymorphisms and passive smoking with cervical cancer,” International Journal of Gynecology & Obstetrics, no. 6, pp. 663–666, 2014. View at Google Scholar
  13. Y. Gao, “Association of Dnmt 1 single-mucleotide polymorphisms and risk of gastric caner,” Chinese Journal of Cancer Prevention and Treatment, no. 6, pp. 394–397, 2015. View at Google Scholar
  14. H. Li, “Association of polymorphisms of DNMT1 and DNMT3B with risk of esophageal cancer,” Labeled Immunoassays and Clinical Medicine, no. 12, pp. 1214–1220, 2015. View at Google Scholar
  15. R. Tao, Z. Chen, P. Wu et al., “The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females,” Tumor Biology, vol. 36, no. 12, pp. 9849–9855, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Kullmann, M. Deryal, M. F. Ong, W. Schmidt, and U. Mahlknecht, “DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population,” Clinical Epigenetics, vol. 5, no. 1, article 7, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-C. Chang, P.-Y. Chang, B. Butler et al., “Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population,” PLoS ONE, vol. 9, no. 10, Article ID e109235, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Mostowska, S. Sajdak, P. Pawlik, M. Lianeri, and P. P. Jagodzinski, “DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population,” Molecular Biology Reports, vol. 40, no. 8, pp. 4893–4899, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Xi, Y. Su, A. B. Fadiel et al., “Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk,” Cancer Epidemiology, vol. 38, no. 6, pp. 708–714, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. W. Lin, Y. L. Cen, Y. Lin et al., “Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk,” Neoplasma, vol. 62, no. 3, pp. 491–499, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. S.-M. Yang, C.-Y. Huang, H.-S. Shiue et al., “Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma,” Toxicology and Applied Pharmacology, vol. 305, pp. 103–110, 2016. View at Publisher · View at Google Scholar · View at Scopus
  22. C. J. Klein, M.-V. Botuyan, Y. Wu et al., “Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss,” Nature Genetics, vol. 43, no. 6, pp. 595–600, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. S. B. Baylin, M. Makos, J. Wu et al., “Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression,” Cancer Cells, vol. 3, no. 10, pp. 383–390, 1991. View at Google Scholar · View at Scopus
  24. C. A. Eads, A. E. Nickel, and P. W. Laird, “Complete genetic suppression of polyp formation and reduction of CPG-island hypermethylation in ApcMin/+ Dnmt1-hypomorphic mice,” Cancer Research, vol. 62, no. 5, pp. 1296–1299, 2002. View at Google Scholar · View at Scopus
  25. W. Chen, N. Gao, Y. Shen, and J.-N. Cen, “Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer,” Journal of Gastroenterology and Hepatology (Australia), vol. 25, no. 4, pp. 823–831, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. B.-G. Zhang, L. Hu, M.-D. Zang et al., “Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development,” Oncotarget, vol. 7, no. 9, pp. 9788–9800, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. Q. Zhang, H. Y. Wang, A. Woetmann, P. N. Raghunath, N. Odum, and M. A. Wasik, “STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes,” Blood, vol. 108, no. 3, pp. 1058–1064, 2006. View at Publisher · View at Google Scholar · View at Scopus