A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Table 1

Characteristics of the included studies in this meta-analysis.

Author	Year	Ethnicity	Cancer type	Genotyping method	Case				Control
					Total	MM	WM	WW	Total	MM	WM	WW
For DNMT1 rs16999593 T/C polymorphism
Wang [12]	2014	Chinese	Cervical cancer	Sequencing	100	48	44	8	100	70	25	5
Gao [13]	2015	Chinese	Gastric cancer	Sequencing	310	180	112	18	420	281	117	22
Li [14]	2015	Chinese	Esophageal cancer	MassARRAY	258	138	80	40	260	127	109	24
He et al. [11]	2014	Chinese	Prostate cancer	MassARRAY	155	94	53	8	155	73	67	15
Sun [7]	2012	Chinese	Breast cancer	MassARRAY	1327	425	224	29	1440	504	202	28
Xiang et al. [6]	2010	Chinese	Breast cancer	PCR-RFLP	305	239	64	2	314	220	89	5
Jiang et al. [9]	2012	Chinese	Gastric cancer	Sequencing	447	283	144	20	961	659	273	29
Yang et al. [10]	2012	Chinese	Gastric cancer	MALDI-TOF	242	141	89	12	294	196	83	15
Tao et al. [15]	2015	Chinese	Breast cancer	Sequencing	234	68	164	2	300	180	105	15
For DNMT1 rs2228611 G/A polymorphism
Gao [13]	2015	Chinese	Gastric cancer	Sequencing	310	167	128	15	420	232	163	25
Li [14]	2015	Chinese	Esophageal cancer	MassARRAY	258	131	85	42	260	119	113	28
He et al. [11]	2014	Chinese	Prostate cancer	MassARRAY	155	82	61	12	155	79	64	12
Xiang et al. [6]	2010	Chinese	Breast cancer	PCR–RFLP	305	125	149	31	314	154	121	39
Yang et al. [21]	2016	Chinese	Renal cell carcinoma	PCR–RFLP	293	152	117	24	293	139	133	21
Yang et al. [10]	2012	Chinese	Gastric cancer	MALDI-TOF	242	132	97	13	285	160	99	26
Sun [7]	2012	Chinese	Breast cancer	MassARRAY	678	341	279	58	733	369	303	61
Mostowska et al. [18]	2013	Polish	Ovarian cancer	PCR–RFLP	159	28	74	57	210	44	94	72
Xi et al. [19]	2014	Chinese	Breast cancer	MALDI-TOF	810	385	362	63	848	432	343	73
Lin et al. [20]	2015	Chinese	Breast cancer	MALDI-TOF	233	107	109	17	236	120	94	22
Khatami et al. [8]	2009	Iranian	Gastric cancer	PCR–RFLP	200	34	50	16	112	32	62	18
For DNMT1 rs2228612 A/G polymorphism
Sun [7]	2012	Chinese	Breast cancer	MassARRAY	675	254	273	148	731	308	290	133
Chang et al. [17]	2014	Chinese	Esophageal cancer	SNPlex	137	52	56	29	357	100	200	57
Chang et al. [17]	2014	Chinese	Stomach cancer	SNPlex	143	43	72	28	357	100	200	57
Chang et al. [17]	2014	Chinese	Liver cancer	SNPlex	158	48	74	36	357	100	200	57
Kullmann et al. [16]	2013	Caucasian	Breast cancer	TaqMan	221	193	28	0	221	180	35	6

Abbreviations: W, wild-type allele; M, mutant-type allele.