A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk

Table 2

Meta-analysis results of the association between DNMT1 rs16999593 (T/C) polymorphism and cancer risk.

Genetic model	Group/subgroup		Heterogeneity test		Statistical model	Test for overall effect
			(%)			OR (95% CI)
CC versus TT	Overall	9	37.5	0.119	F	1.17 (0.92–1.49)	0.213
	Gastric cancer	3	0.0	0.743	F	1.36 (0.93–1.99)	0.117
	Breast cancer	3	48.1	0.146	F	0.93 (0.58–1.48)	0.748
	Sequencing	4	30.1	0.232	F	1.33 (0.90–1.95)	0.149
	MassARRAY	3	66.1	0.052	R	1.01 (0.53–1.93)	0.968
TC versus TT	Overall	9	89.70	<0.001	R	1.29 (0.90–1.84)	0.163
	Gastric cancer	3	00.00	0.540	F	1.36 (1.14–1.61)	0.001
	Breast cancer	3	95.90	<0.001	R	1.53 (0.62–3.80)	0.360
	Sequencing	4	90.30	<0.001	R	2.06 (1.16–3.65)	0.013
	MassARRAY	3	85.40	0.001	R	0.84 (0.49–1.43)	0.517
(TC + CC) versus TT	Overall	9	88.60	<0.001	R	1.28 (0.93–1.72)	0.135
	Gastric cancer	3	00.00	0.720	F	1.36 (1.15–1.60)	<0.001
	Breast cancer	3	95.50	<0.001	R	1.45 (0.62–3.40)	0.388
	Sequencing	4	88.40	<0.001	R	1.99 (1.20–3.28)	0.007
	MassARRAY	3	83.60	0.002	R	0.88 (0.55–1.41)	0.603
CC versus (TC + TT)	Overall	9	48.7	0.049	R	1.03 (0.72–1.49)	0.861
	Gastric cancer	3	0.00	0.635	F	1.22 (0.84–1.78)	0.303
	Breast cancer	3	70.5	0.034	R	0.49 (0.13–1.76)	0.274
	Sequencing	4	62.9	0.044	R	1.00 (0.49–2.04)	0.998
	MassARRAY	3	65.8	0.054	R	1.10 (0.59–2.05)	0.767
C allele versus T allele	Overall	9	81.40	<0.001	R	1.18 (0.95–1.45)	0.127
	Gastric cancer	3	00.00	0.936	F	1.28 (1.11–1.47)	0.001
	Breast cancer	3	91.50	<0.001	R	1.18 (0.71–1.97)	0.529
	Sequencing	4	66.30	0.030	R	1.53 (1.26–1.95)	<0.001
	MassARRAY	3	81.10	0.005	R	0.96 (0.67–1.36)	0.805

Abbreviations: R, random effect model; F, fixed effect model.