Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice

Table 3

The experimental results of sodium selenite in bone marrow micronucleus.

Category	Dose (mg/kg)	Number of tested animals	Check PCE number	MNPCE number	Micronucleus rate ()	PCE/NCE
1/8LD50	2.65	10	10 × 1000	93	9.30 ± 0.423	0.54 ± 0.25
1/4LD50	5.29	10	10 × 1000	95	9.50 ± 0.696	0.43 ± 0.37
1/2LD50	10.59	10	10 × 1000	103	10.3 ± 0.537	0.16 ± 0.21
Negative control group	Distilled water	10	10 × 1000	32	3.20 ± 0.446	1.00 ± 0.38
Positive control group	Cyclophosphamide	10	10 × 1000	124	12.40 ± 1.511	0.70 ± 0.12

Note. indicated that there was a significant difference compared with the negative control group ().