Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice

Table 4

The experimental results of bio-Se in bone marrow micronucleus.

Category	Dose (g/kg)	Number of tested animals	Check PCE number	MNPCE number	Micronucleus rate ()	PCE/NCE
1/8LD50	1.47	10	10 × 1000	28	2.80 ± 0.493	1.08 ± 0.34
1/4LD50	2.95	10	10 × 1000	34	3.40 ± 0.424	1.09 ± 0.41
1/2LD50	5.89	10	10 × 1000	32	3.20 ± 0.437	1.00 ± 0.60
Negative control group	Distilled water	10	10 × 1000	32	3.20 ± 0.557	0.90 ± 0.29
Positive control group	Cyclophosphamide	10	10 × 1000	124	12.40 ± 1.459	0.74 ± 0.17

Note. indicates that there were significant differences with the negative control group ().