Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 4013685, 9 pages
https://doi.org/10.1155/2017/4013685
Research Article

Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease

1Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2Department of Emergency, Wuxi No. 2 People’s Hospital Affiliated Nanjing Medical University, Wuxi 214000, China
3Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China
4Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Correspondence should be addressed to Kejiang Cao; nc.ude.umjn@oacjk

Received 19 December 2016; Revised 9 February 2017; Accepted 12 February 2017; Published 2 March 2017

Academic Editor: Ramazan Akdemir

Copyright © 2017 Xiaoyan Min et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Go, D. Mozaffarian, V. L. Roger et al., “Heart disease and stroke statistics—2013 update: a report from the American Heart Association,” Circulation, vol. 127, no. 1, pp. e6–e245, 2013. View at Publisher · View at Google Scholar
  2. G. Niccoli, S. Giubilato, L. Di Vito et al., “Severity of coronary atherosclerosis in patients with a first acute coronary event: a diabetes paradox,” European Heart Journal, vol. 34, no. 10, pp. 729–741, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Falk, P. K. Shah, and V. Fuster, “Coronary plaque disruption,” Circulation, vol. 92, no. 3, pp. 657–671, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Vucević, D. Radak, T. Radosavljević, D. Mladenović, and I. Milovanović, “[Inflammatory process in atherogenesis: new facts about old flame],” Medicinski pregled, vol. 65, no. 9-10, pp. 388–395, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Mizuno, R. F. Jacob, and R. P. Mason, “Inflammation and the development of atherosclerosis,” Journal of Atherosclerosis and Thrombosis, vol. 18, no. 5, pp. 351–358, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Kashiwagi, A. Tanaka, H. Kitabata et al., “Relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein levels in patients with acute coronary syndrome,” Circulation Journal, vol. 73, no. 7, pp. 1291–1295, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Nakachi, M. Kosuge, K. Hibi et al., “C-reactive protein elevation and rapid angiographic progression of nonculprit lesion in patients with non-ST-segment elevation acute coronary syndrome,” Circulation Journal, vol. 72, no. 12, pp. 1953–1959, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Mizia-Stec, Z. Gasior, B. Zahorska-Markiewicz et al., “Serum tumour necrosis factor-α, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes,” Coronary Artery Disease, vol. 14, no. 6, pp. 431–438, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Zhu, C. Liu, H. Tang et al., “Serum galectin-9 levels are associated with coronary artery disease in Chinese individuals,” Mediators of Inflammation, vol. 2015, Article ID 457167, 13 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Lu, L. Li, H. Yan, Q. Su, J. Huang, and C. Fu, “Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome,” International Journal of Cardiology, vol. 168, no. 6, pp. 5396–5404, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Al Shahi, K. Shimada, K. Miyauchi et al., “Elevated circulating levels of inflammatory markers in patients with acute coronary syndrome,” International Journal of Vascular Medicine, vol. 2015, Article ID 805375, 8 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Hashmi and Q. T. Zeng, “Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease,” Coronary Artery Disease, vol. 17, no. 8, pp. 699–706, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. J.-N. Tang, D.-L. Shen, C.-L. Liu et al., “Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris,” American Journal of the Medical Sciences, vol. 349, no. 2, pp. 130–136, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. W. Zhang, T. Tang, D. Nie et al., “IL-9 aggravates the development of atherosclerosis in ApoE-/-mice,” Cardiovascular Research, vol. 106, no. 3, pp. 453–464, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. I. Gregersen, M. Skjelland, S. Holm et al., “Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis,” PLoS ONE, vol. 8, no. 8, Article ID e72769, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Gotsman, A. Stabholz, D. Planer et al., “Serum cytokine tumor necrosis factor-alpha and interleukin-6 associated with the severity of coronary artery disease: indicators of an active inflammatory burden?” Israel Medical Association Journal, vol. 10, no. 7, pp. 494–498, 2008. View at Google Scholar · View at Scopus
  17. D. A. A. Vignali, “Multiplexed particle-based flow cytometric assays,” Journal of Immunological Methods, vol. 243, no. 1-2, pp. 243–255, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. G. G. Gensini, “A more meaningful scoring system for determining the severity of coronary heart disease,” The American Journal of Cardiology, vol. 51, no. 3, p. 606, 1983. View at Publisher · View at Google Scholar · View at Scopus
  19. U. Ikeda, T. Ito, and K. Shimada, “Interleukin-6 and acute coronary syndrome,” Clinical Cardiology, vol. 24, no. 11, pp. 701–704, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Csiszar and Z. Ungvari, “Synergistic effects of vascular IL-17 and TNFα may promote coronary artery disease,” Medical Hypotheses, vol. 63, no. 4, pp. 696–698, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. K. D. Patel, S. P. Duggan, C. A. Currid et al., “High sensitivity cytokine detection in acute coronary syndrome reveals up-regulation of Interferon Gamma and Interleukin-10 post Myocardial Infarction,” Clinical Immunology, vol. 133, no. 2, pp. 251–256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. S.-H. Li, W.-J. Chen, M. Yan, Y.-W. Shu, and Y.-H. Liao, “Expression of coinhibitory PD-L1 on CD4+CD25+FOXP3+ regulatory T cells is elevated in patients with acute coronary syndrome,” Coronary Artery Disease, vol. 26, no. 7, pp. 598–603, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Szodoray, O. Timar, K. Veres et al., “Th1/Th2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines - Immunological alterations in acute coronary syndrome and stable coronary artery disease,” Scandinavian Journal of Immunology, vol. 64, no. 3, pp. 336–344, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. Q.-W. Ji, M. Guo, J.-S. Zheng et al., “Downregulation of T helper cell type 3 in patients with acute coronary syndrome,” Archives of Medical Research, vol. 40, no. 4, pp. 285–293, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Anguera, F. Miranda-Guardiola, X. Bosch et al., “Elevation of serum levels of the anti-inflammatory cytokine interleukin-10 and decreased risk of coronary events in patients with unstable angina,” American Heart Journal, vol. 144, no. 5, pp. 811–817, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. J. George, S. Schwartzenberg, D. Medvedovsky et al., “Regulatory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques,” Atherosclerosis, vol. 222, no. 2, pp. 519–523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Erbel, L. Chen, F. Bea et al., “Inhibition of IL-17A attenuates atherosclerotic lesion development in ApoE-deficient mice,” Journal of Immunology, vol. 183, no. 12, pp. 8167–8175, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Lin, B. Wu, Z. Lu et al., “Circulating Th22 and Th9 levels in patients with acute coronary syndrome,” Mediators of Inflammation, vol. 2013, Article ID 635672, 10 pages, 2013. View at Publisher · View at Google Scholar
  29. C. Sinning, L. Lillpopp, S. Appelbaum et al., “Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application,” Clinical Research in Cardiology, vol. 102, no. 7, pp. 495–503, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Ye, X. Yang, X. Zhao et al., “Serum chemokine CCL17/thymus activation and regulated chemokine is correlated with coronary artery diseases,” Atherosclerosis, vol. 238, no. 2, pp. 365–369, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Moriates and A. Maisel, “The utility of biomarkers in sorting out the complex patient,” American Journal of Medicine, vol. 123, no. 5, pp. 393–399, 2010. View at Publisher · View at Google Scholar · View at Scopus