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BioMed Research International
Volume 2017, Article ID 4064071, 7 pages
Research Article

Resveratrol Inhibits Propagation of Chlamydia trachomatis in McCoy Cells

1Lycotec Ltd., Granta Park, Cambridge CB21 6GP, UK
2Department of Medical Microbiology, Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health, 18 Gamaleya Str., Moscow 123098, Russia

Correspondence should be addressed to Yuriy K. Bashmakov; moc.loa@62974hsaby

Received 12 June 2017; Accepted 13 September 2017; Published 29 November 2017

Academic Editor: Yiannis Kourkoutas

Copyright © 2017 Ivan M. Petyaev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Resveratrol (RESV), an antifungal compound from grapes and other plants, has a distinct ability to inhibit the Chlamydia (C.) trachomatis developmental cycle in McCoy cells, a classic cell line used for chlamydial research. Inoculation of C. trachomatis with increasing amounts of RESV (from 12.5 to 100 μM) gave a dose-dependent reduction in the number of infected McCoy cells visualized by using monoclonal antibodies against chlamydial lipopolysaccharide. A similar trend has been observed with immunoassay for major outer membrane protein (MOMP). Furthermore, there was a step-wise reduction in the number of C. trachomatis infective progenies caused by the increasing concentrations of RESV. The ability of RESV to arrest C. trachomatis growth in McCoy cells was confirmed by a nucleic acid amplification protocol which revealed dose-dependent changes in mRNAs for different genes of chlamydial developmental cycle (euo, incA, and omcB). Although the precise nature of the antichlamydial activity of RESV is yet to be determined and evaluated in future studies, the observed effect of RESV on C. trachomatis infection was not related to its potential effect on attachment/entry of the pathogen into eukaryotic cells or RESV toxicity to McCoy cells. Similar inhibitory effect was shown for C. pneumoniae and C. muridarum.