Comorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project
Table 1
Demographic, biological variables, depression, anxiety, and alcohol abuse1.
Variable
Transition group (ages 16–25)
Younger adults (ages 26–36)
Older adults (ages 37–64)
value
Gender
0.936
Male
23 (40.3)
27 (38.0)
39 (37.5)
Female
34 (59.7)
44 (62.0)
65 (61.0)
Education
0.008
<High school
13 (22.8)
5 (7.0)
10 ( 9.6)
High school
26 (45.6)
26 (36.6)
36 (34.6)
>High school
18 (31.6)
40 (56.3)
58 (55.8)
Marital status
<0.001
Married
1 (1.7)
12 (16.9)
42 (40.4)
Unmarried
56 (98.3)
59 (83.1)
62 (59.6)
Income
0.972
≤10,000
22 (41.5)
27 (38.0)
39 (37.9)
10,000–20,000
11 (20.7)
17 (23.9)
24 (23.3)
20,001–30,000
6 (11.3)
12 (16.9)
16 (15.5)
>30,000
14 (26.4)
15 (21.1)
24 (23.3)
Genotype
0.793
Sβ0 Thal
1 (1.7)
1 (1.4)
3 ( 2.9)
Sβ+ Thal
1 (1.7)
2 (2.9)
3 ( 2.9)
SC
10 (17.5)
17 (24.3)
29 (27.9)
SS
45 (78.9)
50 (71.4)
69 (66.3)
Seen at SCD specialty center
0.788
Y
27 (49.1)
35 (51.5)
48 (46.1)
N
39 (50.9)
36 (48.5)
56 (53.9)
Number of comorbidities
1.9 (0.2)
2.1 (0.2)
3.0 (0.2)
<0.001
Depression/anxiety
0.014
Y
8 (14.0)
26 (36.6)
33 (31.7)
N
49 (86.0)
45 (63.4)
71 (68.3)
Alcohol abuse
0.419
Y
14 (24.6)
22 (31.0)
36 (34.6)
N
43 (75.4)
49 (69)
68 (65.4)
Lab values2
% F
5.1 (1.1)
2.9 (1.0)
3.9 (0.8)
0.319
HbA
7.7 (2.9)
13.2 (2.6)
13.3 (2.2)
0.262
HbC
8.8 (2.9)
10.9 (2.6)
13.0 (2.1)
0.485
HbS
78.3 (2.9)
71.6 (2.1)
65.8 (2.2)
0.003
HCT
26.3 (0.8)
28.2 (0.7)
27.1 (0.6)
0.238
WBC
11.4 (0.7)
11/0 (0.6)
10.7 (0.5)
0.726
Frequency (%) or mean (SD). Reduced sample size for labs (, 201, 200, 212, 203, and 169 for % F, HbA, HbC, HbS, HbS, HCT, and WBC). Multiple comparisons (Bonferroni, Tukey): significant differences in unadjusted analyses, transition versus younger adults ; transition versus older adults ; younger versus older adults .
