Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 4078346, 10 pages
https://doi.org/10.1155/2017/4078346
Review Article

Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance

Faculty of Information Technology, University of Moratuwa, Katubedda, Moratuwa, Sri Lanka

Correspondence should be addressed to Gamage Upeksha Ganegoda; kl.mou@gahskepu

Received 26 May 2017; Revised 25 July 2017; Accepted 2 August 2017; Published 19 September 2017

Academic Editor: Shashi Kant

Copyright © 2017 Kalupahana Irushi Pamodya Liyanage and Gamage Upeksha Ganegoda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diseases resulting from alterations in gene expressions through mutations in the genes or through changes in the gene expression regulation could be identified through the analysis of RNA expressions. ncRNAs play a significant role in regulation of the gene expression by controlling the expression levels of the coding RNAs and other cellular processes. Discoveries have shown that the human genome is encoded with sequences responsible for the transcription of thousands of ncRNAs. Even though the studies conducted on ncRNAs are still at initial stages, facts established so far display biomarkers that confirm their relationship with certain diseases such as cancers, cardiovascular diseases, and insulin resistance. These studies have been facilitated with high throughput modern sequencing techniques such as microarrays and RNA sequencing. The data obtained through the above analysis are processed with the aid of existing databases, to deduce conclusions on different diagnostic biomarkers and therapeutic targets for specific diseases. This review focuses on the association of ncRNAs in disease prediction, focusing mainly on cardiovascular diseases and disorders caused by insulin resistance. The report also analyzes regulatory functions of ncRNAs and novel approaches used in disease therapeutics.