Review Article
Therapeutic Approaches and Role of ncRNAs in Cardiovascular Disorders and Insulin Resistance
Table 3
ncRNAs affecting both cardiovascular diseases and insulin resistance.
| ncRNA | Insulin resistance effect | Cardiovascular effect | Description |
| miR-34a | Hyperglycemia | Impaired angiogenesis | miR-34a dependent gene regulatory system governs SIRT1 levels and eNOS modifications, both of which affect the two related disease conditions [17]. |
| miR-134 | Diabetes mellitus | Microvascular structure formation and reduced cell migration | Highly expressed in patients with the two disease conditions [17]. |
| miR-130a | Diabetes mellitus | Endothelial Progenitor Cell (EPCs) regulation | Diabetes mellitus patients show decreased proliferation, colony formation, and migration but increased apoptosis in EPCs [17]. |
| miR-24 | High glucose levels | VSMC pathology | miR-24 targets genes causing high glucose induced cell proliferation and migration [17]. |
| miR-504 | Diabetes mellitus | VSMC dysfunction | Upregulation causing both conditions in patients [17]. |
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