Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo

Figure 5

Salinomycin inhibits tumor growth in tumor xenografts. PC-3 tumor xenografts were treated intraperitoneally (i.p.) daily for 3 weeks with either DMSO or salinomycin. The tumor volume of mice was recorded every three days. (a) The excised tumors from DMSO or salinomycin group after 3 weeks. (b) The percentage change of tumor volume. The data are presented as means ± SEM. versus control. (c) The β-catenin, c-Myc, and cyclin D1 protein levels were examined by western blot in fresh xenograft tissues. (d) Representative immunohistochemical staining of β-catenin, c-Myc, and cyclin D1 in paraffin-embedded xenograft tissues. Scale bars: 10 μm.

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