BioMed Research International / 2017 / Article / Fig 5

Research Article

Extrinsic Apoptosis Pathway Altered by Glycogen Synthase Kinase-3β Inhibitor Influences the Net Drug Effect on NSC-34 Motor Neuron-Like Cell Survival

Figure 5

Net effect of changes in intrinsic and extrinsic apoptosis caused by inhibiting glycogen synthase kinase-3β (GSK-3β) in motor neurons. Illustration shows the change in the intrinsic and extrinsic apoptosis pathways affected by the GSK-3β inhibitor. The greater the decrease in GSK-3β activity was, the greater the decrease in intrinsic apoptosis was observed. However, extrinsic apoptosis increased paradoxically.

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