BioMed Research International / 2017 / Article / Fig 5

Research Article

Extrinsic Apoptosis Pathway Altered by Glycogen Synthase Kinase-3β Inhibitor Influences the Net Drug Effect on NSC-34 Motor Neuron-Like Cell Survival

Figure 5

Net effect of changes in intrinsic and extrinsic apoptosis caused by inhibiting glycogen synthase kinase-3β (GSK-3β) in motor neurons. Illustration shows the change in the intrinsic and extrinsic apoptosis pathways affected by the GSK-3β inhibitor. The greater the decrease in GSK-3β activity was, the greater the decrease in intrinsic apoptosis was observed. However, extrinsic apoptosis increased paradoxically.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.