Assessment of Pulmonary Toxicity Induced by Inhaled Toner with External Additives

Table 2

Pathological finding of lung inhaled toner.

Pathological feature	6 months				12 months				22.5 months
	Negative control	1 mg/m^3	4 mg/m^3	16 mg/m^3	Negative control	1 mg/m^3	4 mg/m^3	16 mg/m^3	Negative control	1 mg/m^3	4 mg/m^3	16 mg/m^3
	Infiltration in alveolar macrophages	±	±	+	++ ~ +++	±	±	+	++ ~ +++	±	±	+	+++
Hyperplasia of epithelial cell	—	—	—	±	—	—	— ~ +	+ ~ +++	—	—	—	± ~ +++
Fibrosis	—	—	—	±	—	—	— ~ +	+ ~ ++	—	—	—	± ~ ++
Interstitial infiltration	—	—	—	—	—	—	—	—	—	—	—	—
Tumor incidence rate % (count)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)	9.1 (1)

Grade of changes: — none, ± minimum, + mild, ++ moderate, and +++ remarked.