Research Article
Assessment of Pulmonary Toxicity Induced by Inhaled Toner with External Additives
Table 2
Pathological finding of lung inhaled toner.
| Pathological feature | 6 months | 12 months | 22.5 months | Negative control | 1 mg/m3 | 4 mg/m3 | 16 mg/m3 | Negative control | 1 mg/m3 | 4 mg/m3 | 16 mg/m3 | Negative control | 1 mg/m3 | 4 mg/m3 | 16 mg/m3 | | | | | | | | | | | | |
| Infiltration in alveolar macrophages | ± | ± | + | ++ ~ +++ | ± | ± | + | ++ ~ +++ | ± | ± | + | +++ | Hyperplasia of epithelial cell | — | — | — | ± | — | — | — ~ + | + ~ +++ | — | — | — | ± ~ +++ | Fibrosis | — | — | — | ± | — | — | — ~ + | + ~ ++ | — | — | — | ± ~ ++ | Interstitial infiltration | — | — | — | — | — | — | — | — | — | — | — | — | Tumor incidence rate % (count) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 9.1 (1) |
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Grade of changes: — none, ± minimum, + mild, ++ moderate, and +++ remarked.
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