Inhibitory Activities of Stauntonia hexaphylla Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant

Table 2

Inhibitory effect of compounds isolated from Stauntonia hexaphylla leaves on rat lens aldose reductase (RLAR).

Compounds	IC50
3-(3,4-Dihydroxyphenyl)-propionic acid (1)	>1000
Chlorogenic acid (2)	8.35 ± 0.45
Neochlorogenic acid (3)	72.03 ± 25.77
Calceolarioside B (4)	23.99 ± 2.30
Luteolin-3′-O-β-D-glucopyranoside (5)	7.34 ± 0.35
Quercetin-3-O-β-D-glucopyranoside (6)	10.40 ± 1.38
Luteolin-7-O-β-D-glucopyranoside (7)	16.10 ± 1.20
	18.09 ± 1.30

IC₅₀ value was defined as a mean ± SEM of half-maximal inhibitory concentration from three independent experiments performed in duplicate.
is the positive control for aldose reductase.