Research Article

Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea

Table 1

Antibiotics related ADR frequency and most common symptoms according to organ class (according to the preferred terms of MedDRA coding system).

AntibioticPatients, (%)Symptom organ classFrequency of  
ADRs, (%)

Penicillin204 (16)Skin and subcutaneous tissue 
Gastrointestinal 
Allergic
88 (43.1) 
61 (29.9) 
22 (10.8)

Quinolone204 (16)Skin and subcutaneous tissue 
Gastrointestinal 
Nervous system
98 (48.0) 
66 (32.4) 
16 (7.8)

3rd cephalosporin190 (14.9)Skin and subcutaneous tissue 
Gastrointestinal 
Allergic
86 (45.3) 
79 (41.6) 
18 (9.5)

2nd cephalosporin144 (11.3)Skin and subcutaneous tissue 
Gastrointestinal 
Nervous system
68 (47.2) 
53 (36.8) 
12 (8.3)

Glycopeptide134 (10.5)Skin and subcutaneous tissue 
Allergic 
Blood and lymphatic system
83 (61.9) 
24 (17.9) 
14 (10.4)

Metronidazole61 (4.8)Gastrointestinal 
Skin and subcutaneous tissue 
Nervous system
46 (75.4) 
12 (19.7) 
5 (8.2)

Antituberculosis medication61 (4.8)Skin and subcutaneous tissue 
Gastrointestinal 
Hepatobiliary 
Allergic
33 (54.1) 
7 (11.5) 
6 (9.8) 
6 (9.8)

1st cephalosporin53 (4.2)Skin and subcutaneous tissue 
Nervous system
32 (60.4) 
18 (34.0) 
6 (11.3)

Carbapenem43 (3.4)Skin and subcutaneous tissue 
Allergic 
Gastrointestinal
19 (44.2) 
10 (23.3) 
8 (18.6)

Antifungal33 (2.6)Allergic 
Skin and subcutaneous tissue 
Cardiac
12 (36.4) 
9 (27.3) 
6 (18.2)

Antiviral21 (1.6)Skin and subcutaneous tissue 
Gastrointestinal 
Blood and lymphatic system
8 (38.1) 
5 (23.8) 
3 (14.3)

Aminoglycoside20 (1.6)Skin and subcutaneous tissue 
Gastrointestinal 
Renal and urinary
12 (60.0) 
4 (20.0) 
2 (10.0)

Macrolide17 (1.3)Gastrointestinal 
Skin and subcutaneous tissue 
Nervous system
7 (41.2) 
5 (29.4) 
3 (17.6)

Sulfonamide16 (1.3)Gastrointestinal 
Skin and subcutaneous tissue 
Renal and urinary
9 (56.2) 
5 (31.2) 
2 (12.5)

4th cephalosporin16 (1.3)Skin and subcutaneous tissue 
Gastrointestinal 
Nervous system
9 (56.2) 
5 (31.2) 
3 (18.8)

Tetracycline13 (1)Gastrointestinal 
Skin and subcutaneous tissue
8 (61.5) 
2 (15.4)

Antimalarial12 (0.9)Skin and subcutaneous tissue 
Gastrointestinal 
Nervous system
5 (41.7) 
4 (33.3) 
4 (33.3)

Lincosamide9 (0.7)Skin and subcutaneous tissue 
Gastrointestinal
7 (77.8) 
2 (22.2)

Polymyxin3 (0.2)Renal and urinary 
Skin and subcutaneous tissue
2 (66.7) 
1 (33.3)

Monobactam1 (0.1)Allergic 
Skin and subcutaneous tissue
1 (100) 
1 (100)

Linezolid1 (0.1)Blood and lymphatic system1 (100)

ADRs: adverse drug reactions.