Research Article

Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea

Table 2

Frequency of ADRs in symptom organ class and most common causative antibiotics (according to the preferred terms of MedDRA coding system).

Symptom organ classPatients, (%)AntibioticsFrequency of ADRs, (%)

Skin and subcutaneous tissue disorders576 (45.1)Quinolone 
Penicillin 
3rd cephalosporin
98 (17.0) 
88 (15.3) 
86 (14.9)

Gastrointestinal disorders416 (32.6)3rd cephalosporin 
Quinolone 
Penicillin
79 (19.0) 
66 (15.9) 
61 (14.7)

Allergic disorders125 (9.8)Glycopeptide 
Penicillin 
3rd cephalosporin
24 (19.2) 
22 (17.6) 
18 (14.4)

Nervous system disorders91 (7.1)Quinolone 
3rd cephalosporin 
2nd cephalosporin
16 (17.6) 
14 (15.4) 
12 (13.2)

Blood and lymphatic system disorders68 (5.3)Penicillin 
Glycopeptide 
3rd cephalosporin
20 (29.4) 
14 (20.6) 
8 (11.8)

Cardiac disorders43 (3.4)Quinolone 
3rd cephalosporin 
2nd cephalosporin
8 (18.6) 
7 (16.3) 
7 (16.3)

General disorders and administration site conditions31 (2.4)Quinolone 
Antiviral agent
11 (61.1) 
2 (11.1)

Renal and urinary disorders24 (1.9)Glycopeptide 
Penicillin 
Antifungal agent
5 (20.8) 
5 (20.8) 
3 (12.5)

Respiratory, thoracic, and mediastinal disorders23 (1.8)3rd cephalosporin 
Antifungal agent 
Penicillin
6 (26.1) 
5 (21.7) 
4 (17.4)

Hepatobiliary disorders23 (1.8)Anti-TB medication 
Penicillin 
Carbapenem
6 (26.1) 
3 (13.0) 
3 (13.0)

Eye disorder5 (0.4)Anti-TB medication 
Penicillin
4 (80.0) 
1 (20.0)

Psychiatric disorders4 (0.3)2nd cephalosporin 
Carbapenem 
Quinolone
2 (50.0) 
1 (25.0) 
1 (25.0)

Musculoskeletal and connective tissue disorders2 (0.2)Penicillin 
Antifungal agent
1 (50.0) 
1 (50.0)

ADRs: adverse drug reactions; TB: tuberculosis.