Identification of Key Pathways and Genes in Advanced Coronary Atherosclerosis Using Bioinformatics Analysis

Table 7

KEGG analysis based on module D.

GOID	GO term	Ontology source	Term value	Nr. genes	Associated genes found
GO:0005130	Pathogenic Escherichia coli infection	KEGG_01.03.2017		3.00	ABL1, RHOA, TUBA4A]
GO:0004071	Sphingolipid signaling pathway	KEGG_01.03.2017		5.00	PPP2CB, PPP2R5A, PPP2R5C, RAF1, RHOA]
GO:0004270	Vascular smooth muscle contraction	KEGG_01.03.2017		5.00	ACTG2, PPP1CB, PPP1R12A, RAF1, RHOA]
GO:0005210	Colorectal cancer	KEGG_01.03.2017		3.00	CYCS, RAF1, RHOA]
GO:0004270	Vascular smooth muscle contraction	KEGG_01.03.2017		5.00	ACTG2, PPP1CB, PPP1R12A, RAF1, RHOA]
GO:0004510	Focal adhesion	KEGG_01.03.2017		12.00	CCND2, EGFR, IGF1R, ITGB3, LAMA5, LAMC1, PPP1CB, PPP1R12A, RAF1, RHOA, TLN2, VCL]
GO:0004611	Platelet activation	KEGG_01.03.2017		5.00	ITGB3, PPP1CB, PPP1R12A, RHOA, TLN2]
GO:0004720	Long-term potentiation	KEGG_01.03.2017		3.00	PPP1CB, PPP3CB, RAF1]
GO:0004810	Regulation of actin cytoskeleton	KEGG_01.03.2017		9.00	EGFR, ENAH, ITGB3, PPP1CB, PPP1R12A, RAF1, RHOA, RRAS, VCL]
GO:0005210	Colorectal cancer	KEGG_01.03.2017		3.00	CYCS, RAF1, RHOA]
GO:0004071	Sphingolipid signaling pathway	KEGG_01.03.2017		5.00	PPP2CB, PPP2R5A, PPP2R5C, RAF1, RHOA]
GO:0004152	AMPK signaling pathway	KEGG_01.03.2017		5.00	IGF1R, PPP2CB, PPP2R5A, PPP2R5C, RHEB]
GO:0004520	Adherens junction	KEGG_01.03.2017		4.00	EGFR, IGF1R, RHOA, VCL]
GO:0004730	Long-term depression	KEGG_01.03.2017		3.00	IGF1R, PPP2CB, RAF1]
GO:0005214	Glioma	KEGG_01.03.2017		3.00	EGFR, IGF1R, RAF1]
GO:0005218	Melanoma	KEGG_01.03.2017		3.00	EGFR, IGF1R, RAF1]
GO:0003015	mRNA surveillance pathway	KEGG_01.03.2017		6.00	PAPOLA, PPP1CB, PPP2CB, PPP2R5A, PPP2R5C, SRRM1]
GO:0004071	Sphingolipid signaling pathway	KEGG_01.03.2017		5.00	PPP2CB, PPP2R5A, PPP2R5C, RAF1, RHOA]
GO:0004114	Oocyte meiosis	KEGG_01.03.2017		6.00	IGF1R, PPP1CB, PPP2CB, PPP2R5A, PPP2R5C, PPP3CB]
GO:0004152	AMPK signaling pathway	KEGG_01.03.2017		5.00	IGF1R, PPP2CB, PPP2R5A, PPP2R5C, RHEB]
GO:0004261	Adrenergic signaling in cardiomyocytes	KEGG_01.03.2017		6.00	PPP1CB, PPP2CB, PPP2R5A, PPP2R5C, TPM1, TPM2]
GO:0004730	Long-term depression	KEGG_01.03.2017		3.00	IGF1R, PPP2CB, RAF1]
GO:0005210	Colorectal cancer	KEGG_01.03.2017		3.00	CYCS, RAF1, RHOA]