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ā | Gender | Age of onset (years) | Family history | Medical history | Inaugural symptoms | Clinical manifestations on first attack, EDSS score |
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Patient 1 | F | 17 | Goitre | None | Dysarthria + weakness of lower limbs + numbness in upper limbs | Thermic hyperesthesia + tactile hypoesthesia + upper limb dystonia + cerebellar ataxia. EDSS = 3.5 |
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Patient 2 | F | 16 | Epilepsy | Allergic rhinitis | Facial paralysis + diplopia + dizziness | 6th nerve paralysis + tetrapyramidal syndrome + vestibular syndrome + cerebellar ataxia. EDSS = 3 |
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Patient 3 | F | 3 | None | None | Dysarthria + gait disorder | Dysarthria + static and kinetic cerebellar syndrome. EDSS = 3 |
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Patient 4 | M | 10 | None | None | Seizures + altered consciousness + gait disorder + decreased vision + vomiting | Dysarthria + dystonia + cerebellar syndrome + proprioceptive dysfunction + nystagmus + 7th nerve paralysis + decreased vision. EDSS = 2 |
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Patient 5 | F | 17 | None | Type 1 diabetes | Decreased vision + sphincter dysfunction + weakness and numbness of lower limbs | Paraparesis + pyramidal syndrome + cerebellar syndrome + proprioceptive dysfunction. EDSS = 4.5 |
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Patient 6 | M | 10 | None | Type 1 diabetes | Right hemibody weakness + paresthesia | Right hemiplegia. EDSS = 5 |
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Patient 7 | F | 17 | Bipolar disorder | None | Left hemibody weakness + paresthesia | Left hemiparesis + tactile and pain sensory dysfunction. EDSS = 3.5 |
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Patient 8 | M | 4 | None | Asthma | Headache + left hemibody weakness + hand movement disorder + vomiting | Left hemiparesis + central facial paralysis + hand dystonia. EDSS = 3.5 |
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Patient 9 | F | 16 | None | None | Left upper limb weakness + paresthesia | Left pyramidal syndrome + hemibody hypoesthesia + sensory level C4. EDSS = 2 |
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Patient 10 | F | 14 | None | None | Dizziness + cervical movement disorder + vomiting | Cervical dystonia + pyramidal syndrome + vestibular syndrome + paraparesis. EDSS = 4 |
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Patient 11 | M | 12 | None | None | Dizziness + vomiting + diplopia | Vestibular syndrome + pyramidal syndrome. EDSS = 1.5 |
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Patient 12 | F | 15 | None | None | Tremor of upper limbs + convergent strabismus + diplopia + urinary dysfunction | Dysarthria + right convergent strabismus + nystagmus + cerebellar syndrome. EDSS = 2 |
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Patient 13 | F | 7 | None | None | Gait disorder + hand movement disorder | Dystonia + myoclonus + tremor. EDSS = 3 |
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Patient 14 | F | 17 | None | Hypothyroidism | Lower limb weakness + hemibody paresthesia + facial paralysis + hand movement disorder | Spastic paraparesis + pyramidal syndrome + hemibody hypoesthesia. EDSS = 3 |
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Patient 15 | M | 4.5 | None | None | Hemibody weakness + facial paralysis | Right hemiparesis. EDSS = 2 |
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Patient 16 | F | 12 | None | None | Strabismus + facial paralysis + gait disorder + diplopia + dizziness + swallowing difficulties | Pseudobulbar syndrome + proprioceptive dysfunction. EDSS = 6 |
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Patient 17 | F | 17 | None | None | Four limbs weakness + paresthesia | Left lower limb paresis + thermic and pain sensory dysfunction + proprioceptive dysfunction. EDSS = 4.5 |
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Patient 18 | F | 16 | None | None | Paresthesia + tremor + facial paralysis + lower limb weakness | Right hemiparesis + tremor + kinetic cerebellar syndrome + pyramidal syndrome. EDSS = 2,5 |
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Patient 19 | F | 4 | None | None | Dysarthria + hemibody weakness | Spasmodic laughter and weeping + dysarthria + tetraparesis + cerebellar syndrome. EDSS = 4,5 |
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Patient 20 | F | 8 | None | None | Left hemibody weakness | Left hemiparesis. EDSS = 2 |
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Patient 21 | F | 13 | None | Type 1 diabetes | Paresthesia + hemibody weakness | Flaccid paraparesis + sensory level D3. EDSS = 4 |
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