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BioMed Research International
Volume 2017, Article ID 4384823, 8 pages
https://doi.org/10.1155/2017/4384823
Research Article

Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand

1School of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
2Suranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand
3School of Family Medicine, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
4Department of Surgery, Surin Hospital, Surin 32000, Thailand
5Buriram Hospital, Buriram 31000, Thailand
6School of Oncology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
7School of Pathology, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
8School of Preclinic, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
9Faculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima 30000, Thailand

Correspondence should be addressed to Taweesak Tongtawee; ht.ca.tus@t.kaseewat

Received 23 August 2017; Accepted 5 December 2017; Published 27 December 2017

Academic Editor: Gail B. Mahady

Copyright © 2017 Taweesak Tongtawee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics. Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (). We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57–7.23; and GG: OR = 8.32; 95% CI = 2.94–11.42; ), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions. Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.