Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand
Table 4
The distribution of the clinicopathological characteristics of gastric cancer related to expression of CD44 and polymorphisms (multivariate Cox proportional hazards regression model analysis).
Clinicopathological characteristics of gastric cancer ( = 162)
Expression of CD 44 protein (%)
OR (95% CI)
value
Negative
Positive
Location of tumor (%)
(i) Lower
7.69
58.84
3.82 (1.31–5.84)
0.01
Tumor size (%)
(i) ≥70 mm
7.69
48.71
5.24 (3.28–8.18)
0.02
Histologic type (%)
(i) Undifferentiated
5.12
53.84
4.19 (4.18–10.29)
0.03
Lymphatic invasion (%)
(i) Absent
41.02
7.69
4.12 (1.08–6.34)
0.01
(ii) Present
12.82
38.46
1.09 (1.19–2.47)
0.061
Pathological T stage (%)
(i) T3-T4
20.51
46.15
2.09 (1.02–3.07)
0.04
Pathological TNM stage (%)
(i) III
5.12
28.02
3.46 (1.82–5.24)
0.02
(ii) IV
2.56
20.51
4.33 (3.47–8.89)
0.01
Residual tumor [ = 29] (%)
(i) No
58.97
15.38
3.29 (1.87–4.39)
0.02
(ii) Microscopic
2.56
10.25
0.94 (1.31–3.83)
0.057
5-year survival (available = 118) (%)
55.08
18.64
2.26 (2.01–4.89)
0.03
Multivariate Cox proportional hazards regression model analysis was used to analyze the data. OR, odds ratio; CI, confidence interval. Adjustments were performed by incorporating all of the relevant factors, such as age, gender, underlying disease, and family history of gastric cancer into the analysis. Significance is set at < 0.05.
