Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway

<div>A high concentration of UA (20 mg/dL) induces endothelial dysfunction. (a) UA significantly reduced NO release from HUVECs in a time-dependent manner. (b) UA significantly reduced eNOS protein expression of HUVECs in a time-dependent manner. 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BioMed Research International

fig1

Figure 1

Figure 1: Uric Acid Induces Endothelial Dysfunction by Activating the HMGB1/RAGE Signaling Pathway 