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BioMed Research International
Volume 2017, Article ID 4515701, 6 pages
https://doi.org/10.1155/2017/4515701
Research Article

Complex Segregation Analysis Provides Evidence for Autosomal Dominant Transmission in the Chinese Han Families with Ankylosing Spondylitis

1Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical University, Dongguan, China

Correspondence should be addressed to Jieruo Gu; moc.361@oureijug

Received 5 January 2017; Accepted 17 September 2017; Published 3 December 2017

Academic Editor: Joao Eurico Fonseca

Copyright © 2017 Yutong Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Familial aggregation of ankylosing spondylitis (AS) has been frequently noticed. However, the mode of inheritance in AS remains poorly understood. Our aim was to determine the mode of inheritance best fitting the observed transmission pattern of AS families. Methods. Families with 5 or more AS patients diagnosed with 1984 modified New York criteria were recruited. We performed complex segregation analysis for a binary trait in regressive multivariate logistic models. The inheritance models, including sporadic, major gene, environmental, general, and other 9 models, were compared by likelihood ratio tests and Akaike’s Information Criterion. Results. This research included 9 Chinese Han AS families with a total number of 315 persons, including 74 patients. First, familial association was determined. Sporadic with familial association model was rejected when compared with either the general model or the homogeneous general model (). The environmental model was also rejected when compared with general models (). Mendelian dominate mode fitted best in 5 AS families, while Tau AB free model best explained the mode of inheritance in these AS families. Conclusion. This study provided evidence in support of Mendelian dominant mode and firstly discovered a non-Mendelian mode called tau AB free inheritance mode in AS.