Research Article

Complex Segregation Analysis Provides Evidence for Autosomal Dominant Transmission in the Chinese Han Families with Ankylosing Spondylitis

Table 3

Parameter estimated from segregation analysis in various models in nine AS families.

ParameterModel 2Model 5Model 6Model 7Model 8Model 9Model 10Model 11Model 12Model 13
SporadicGeneralHomogenousEnvironmentTau AB freeCodominantDominantRecessiveAdditiveDecreasing

<0.001<0.001<0.001<0.001<0.001<0.001

with Model 5 (general model); §parameters were fixed at the values indicated; Model 2 refers to sporadic model with equal family association parameters; Mendelian increasing model cannot be estimated with the parameters settled in the model.