Prevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of China

Table 6

The relationship between gene mutation and drug resistance in 156 MDR isolates.

Drug-resistant phenotype	Number of isolates	Locus	Number (%) of isolates
			Mutation	Without mutation
OFX		gyrA
Resistant	66		53 (80.3)	13 (19.7)	91.086	<0.001
Susceptible	90		5 (5.6)	85 (94.4)
		gyrB
Resistant	66		4 (6.1)	62 (93.9)	0.007	0.93
Susceptible	90		4 (4.4)	86 (95.6)
KAN		rrs
Resistant	26		19 (73.1)	7 (26.9)		<0.00
Susceptible	130		1 (0.8)	129 (99.2)
		eis
Resistant	26		4 (15.4)	22 (84.6)		0.00
Susceptible	130		1 (0.8)	129 (99.2)

correction; isher’s exact test.