MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development

Figure 6

Network of miRNAs and TFs. (a) Network of TFs and pivotal miRNAs confirmed in comparison of DFs and SFs. (b) The core network shrank by extracting the hub TFs from (a). The red nodes represent abundantly expressed miRNAs both in DFs and SFs. The yellow nodes represent upregulated and the green nodes represent downregulated miRNAs. The pink rhombic nodes represent TFs affected by differentially expressed miRNAs. (c) Network of TFs and critical miRNAs confirmed in comparison of DFs versus SFs as well as DFs versus small follicles. (d) The relevant core network constructed by the relations between the hub TFs and miRNAs with correspondence to (c). The red nodes represent upregulated miRNAs and green nodes represent downregulated miRNAs. The purple rhombic nodes represent TFs affected by both differentially expressed miRNAs. The orange lines display the connections of TFs and miRNA which had evidenced basis [43–46].

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